Compounded semaglutide
Direct Meds review
Weekly semaglutide injections from Direct Meds cost $297 a month, and that single charge includes the doctor review, the vials, supplies and delivery. Membership fees don't exist here. Instead of monthly boxes, a three-month supply arrives together while billing stays monthly.
Visit Direct Meds →We earn a commission if you start care through this link, at no extra cost to you.
Is it right for you?
Worth a look if
- You like having a quarter's worth of medication in the fridge instead of reordering each month.
- A LegitScript-certified seller matters to you.
- You might want a needle-free option later, since Direct Meds also offers semaglutide as under-the-tongue drops.
Skip it if
- Your address is in Louisiana or Mississippi. Direct Meds says telehealth weight-loss prescribing is banned there.
- You need to know now what a higher maintenance dose will cost.
What's included
One option appears on the semaglutide page: the 90-day supply, shipped at once and billed at $297 a month. The page lists free shipping, no membership fees, no hidden fees and no long-term commitment. It also mentions 30, 90, 180 and 360 day supplies, though only the 90-day plan is shown with a price.
The medication is made by 503B pharmacies, the FDA category built for larger sterile batches. Which one fills yours depends on your state. CraftedRx covers most of the map, while ChemistryRx serves Alabama, California, Connecticut, North and South Carolina, and Washington.
Direct Meds keeps a medical director on staff and says its prescribers are checked for licensure in each state. Nurses stay available between refills, and your provider can be reached through the portal.
From sign-up to refills
- Select semaglutide injections and pay the first month up front.
- Answer the health questions in your patient portal.
- Expect a provider to look at your chart within a day. Direct Meds says it's often done in less than five hours.
- After approval, your kit leaves the pharmacy in cold packaging with UPS next-day service. Orders placed Friday through Sunday ship the following Monday.
- Near the end of your supply, message your provider through the portal for a dose check and a fresh prescription.
See Direct Meds's semaglutide plans
$297 a month for compounded semaglutide.
Go to Direct Meds →We earn a commission if you start care through this link, at no extra cost to you.
What's good, what isn't
What's good
- Direct Meds refunds the whole first payment if your prescription isn't approved.
- You know the pharmacy up front, since the FAQ lists CraftedRx and ChemistryRx by state.
- Deliveries go by UPS next-day in a temperature-controlled package, with insurance on every shipment.
What isn't
- Direct Meds takes the first month's payment before any provider has looked at your answers.
- After 24 hours, the terms say a prescription order generally can't be canceled.
- Direct Meds won't take back prescription medication unless it was wrong, damaged, unshipped or denied.
Read these terms first
- Three months shipped, one month billed
- Direct Meds bills monthly for a supply that arrives in one 90-day shipment. Ask how the remaining months are handled before you order, in case you stop early.
- Stopping future charges
- Per the terms, auto-refill can be switched off in your account up to 48 hours before a charge. Direct Meds' FAQ also accepts cancellations by email or phone.
- Dose and price
- Only one price appears for injectable semaglutide. Confirm with support that $297 still applies once your prescriber raises the weekly dose.
- FDA warning letter
- FDA sent Direct Meds a warning letter in September 2025. Read what it covers.
Price
Direct Meds costs $297 a month for compounded semaglutide. That is the starting dose, and it rises as your dose does.
How we got $297
The arithmeticOne month = 30.4375 days
Direct Meds advertises
Read on Direct Meds's own site
$297.00
The card is charged $297.00 — exactly what it advertises
+ $0.00
And it is charged once a calendar month
+ $0.00
A real month$297.00
Reconciles exactly — the advertised figure is a real month.
The price above is the starting dose, and it rises as your dose does. This seller does not publish how far, so treat it as an entry price rather than what you will be paying in six months.
Where it sits, and what costs less
$54median $199$325+
330 cheaper · 87%42 dearer · 11%
The most expensive 10 sellers charge between $325 and $540 a month.
- Fidelity Medical Clinicstarting dose$54
- Collective$76
- NextMeds$79
- Lean Meds$79
- RxPepsDirectstarting dose$80
- Direct Meds$297
Another 325 sellers are cheaper than Direct Meds. The whole cheapest list →
Where it says it operates
The Service is available only in states where we offer it and only to eligible users who accept this Agreement. You represent that you are located in the same state as your shipping address when consulting with a Provider.
Read on its own site in August 2026. It names no state.
Direct Meds against other sellers
Side by side on what each one bills over a calendar month.
- Direct Meds vs MEDVi — $28 a month apart.
What else this seller sells
The same seller appears in our data for one other medication.
- tirzepatide — $399 a month
Each figure is a real month for that medication, and none of it is part of the compounded semaglutide price above. How the two molecules compare at every seller that sells both: compounded semaglutide vs compounded tirzepatide.
FDA has written to this seller
In , FDA sent warning letter 716822 to directmeds.com, Inc. dba DirectMeds (Bluffdale, UT). The letter’s subject:
Unlawful Sale of Unapproved and Misbranded Drugs to United States Consumers Over the Internet (Telehealth)
Read the letter on fda.gov · The letter names directmeds.com — the same site this page links to.
This seller stays in the index, at its real price. A warning letter is something you should see and weigh for yourself — an index that quietly dropped the worst records would be least useful exactly when it matters most. We earn a commission if you use the link on this page, and the letter is shown beside it. How we screen for these →
Common questions about Direct Meds
- Is Direct Meds legit for semaglutide?
- Direct Meds holds LegitScript certification and uses U.S. 503B compounding pharmacies registered with the FDA. It works as a platform, and independent licensed providers make the prescribing decision. Compounded semaglutide isn't Wegovy or Ozempic, and the FDA hasn't approved it.
- How much does Direct Meds semaglutide cost?
- Injectable semaglutide is $297 a month with the provider review, supplies and shipping included. Direct Meds' compounded tirzepatide costs $399 a month, and a sublingual semaglutide is sold at its own price.
- Can I use insurance or HSA at Direct Meds?
- Direct Meds quotes one bundled cash price, and its site says HSA and FSA payments are accepted. Prescriptions have to be filled at its network pharmacies.
- How do I cancel Direct Meds?
- Turn off auto-refill in your account at least 48 hours before the next processing date, or email or phone support. There's no contract to break. Direct Meds sends notice 5 to 7 days before each charge, and it won't refund medication you already have.
Start semaglutide with Direct Meds
Prescribed online by a licensed clinician if you qualify.
Go to Direct Meds →We earn a commission if you start care through this link, at no extra cost to you.
More semaglutide sellers to weigh up
- MEDGm$299a monthGo to MEDGm →
- Willow$299a monthGo to Willow →
- Found$314a monthGo to Found →
Listed by price. We earn a commission if you start care through this link, at no extra cost to you.