Price comparison
Compounded semaglutide vs compounded tirzepatide: what the step up costs
Quick answer
Moving up to tirzepatide costs more at almost every seller that sells both — 332 of 365, with a median step up of $81 a month. The median compounded semaglutide month is $199; compounded tirzepatide’s is $272. At 33 sellers the step up costs nothing at all.
The step up, in one table1
| Semaglutide | Tirzepatide | |
|---|---|---|
| Sellers tracked | 431 | 402 |
| With a computed monthly cost | 397 | 384 |
| Median month | $199 | $272 |
| Cheapest month | $54 | $61 |
Both columns are true calendar months, computed by the same method on this index and on Compounded Tirzepatide, our sister index — so the gap between them is a real gap, not two different ways of counting a month.
Where the step up is smallest2
If you are staying with the seller you already use, this is the number that matters: what that same company charges for tirzepatide. At 65 sellers the difference is $50 a month or less. These are the twenty smallest.
| Seller | Semaglutide | Tirzepatide | Step up |
|---|---|---|---|
| Ascend Medical · entry price | $122 | $130 | +$8 |
| Collective | $76 | $86 | +$10 |
| TrueMe | $141 | $151 | +$10 |
| WePeptideRx · entry price | $189 | $202 | +$13 |
| Lavender Sky Health · entry price | $141 | $157 | +$16 |
| Youth & Soul | $162 | $180 | +$18 |
| MaxLife · entry price | $100 | $120 | +$20 |
| OurView Health | $111 | $131 | +$20 |
| Strut Health · entry price | $131 | $151 | +$20 |
| Brightmeds | $131 | $151 | +$20 |
| Recovery Delivered · entry price | $203 | $223 | +$20 |
| VitaStir · entry price | $136 | $158 | +$22 |
| Citizen Meds · entry price | $160 | $182 | +$22 |
| YOURx Health | $169 | $192 | +$23 |
| Neo Soma Healthcare · entry price | $216 | $239 | +$23 |
| EverSlim · entry price | $113 | $136 | +$23 |
| Nova MD · entry price | $178 | $202 | +$24 |
| EdgeRx | $202 | $228 | +$26 |
| Refills | $242 | $271 | +$28 |
| NextMeds | $79 | $109 | +$30 |
“Entry price” marks a row where one of the two figures holds at the starting dose only and climbs as the dose does. Tirzepatide prices link to the seller’s page on Compounded Tirzepatide, where the arithmetic behind each one is shown.
Where tirzepatide costs no more1
At these sellers the tirzepatide month is the same as the semaglutide one, or lower:
- HeliMeds — semaglutide $260, tirzepatide $162 (an entry price for tirzepatide, which rises with the dose).
- June Health — semaglutide $283, tirzepatide $202 (an entry price for tirzepatide, which rises with the dose).
- FMmeds — semaglutide $225, tirzepatide $145.
- Boston Medical Group — semaglutide $325, tirzepatide $253 (an entry price for tirzepatide, which rises with the dose).
- Fifty 410 — semaglutide $199, tirzepatide $133 (an entry price for tirzepatide, which rises with the dose).
- Glam Health — semaglutide $254, tirzepatide $189.
- Rebody Health — semaglutide $326, tirzepatide $272 (an entry price for tirzepatide, which rises with the dose).
- Velvet Rx — semaglutide $325, tirzepatide $283.
- FitFlow — semaglutide $175, tirzepatide $134.
- Cora Health — semaglutide $175, tirzepatide $135.
- Jyra Health — semaglutide $169, tirzepatide $133.
- VevaRX — semaglutide $189, tirzepatide $156.
- GobyMeds — semaglutide $169, tirzepatide $145 (an entry price for tirzepatide, which rises with the dose).
- PreventiveMD — semaglutide $121, tirzepatide $97 (an entry price for tirzepatide, which rises with the dose).
- Bloom MD — semaglutide $275, tirzepatide $253 (an entry price for tirzepatide, which rises with the dose).
- RxPepsDirect — semaglutide $80, tirzepatide $61 (an entry price for tirzepatide, which rises with the dose).
- Bayan Health — semaglutide $129, tirzepatide $119.
- Valhalla Vitality — semaglutide $108, tirzepatide $100 (an entry price for tirzepatide, which rises with the dose).
- Aspen — semaglutide $303, tirzepatide $299.
- Teleios Health — semaglutide $99, tirzepatide $99.
- Fresh Day Meds — semaglutide $140, tirzepatide $140 (an entry price for tirzepatide, which rises with the dose).
- LifeRx.md — semaglutide $174, tirzepatide $174.
- Ivy Rx — semaglutide $190, tirzepatide $190.
- LifespanningRx — semaglutide $213, tirzepatide $213 (an entry price for tirzepatide, which rises with the dose).
- CaliberRx — semaglutide $232, tirzepatide $232.
- ARSYNL Rx — semaglutide $233, tirzepatide $233.
- DadVantage Men's Health — semaglutide $268, tirzepatide $268.
- Found — semaglutide $289, tirzepatide $289.
- Henry Meds — semaglutide $301, tirzepatide $301.
- MDExam — semaglutide $301, tirzepatide $301.
- MyStart Health — semaglutide $303, tirzepatide $303.
- EllieMD — semaglutide $325, tirzepatide $325.
- Gaya Wellness — semaglutide $405, tirzepatide $405 (an entry price for tirzepatide, which rises with the dose).
What the extra buys3
Two randomized trials have compared the approved drugs head to head, and both found tirzepatide ahead. In SURMOUNT-5, in adults with obesity and without diabetes, weight fell by 20.2% on tirzepatide and 13.7% on semaglutide over 72 weeks. SURPASS-2, in type 2 diabetes, compared tirzepatide with semaglutide at its 1 mg diabetes dose and found tirzepatide lowered blood sugar further at every dose tested.
Neither trial tested a compounded preparation, and neither answers whether a given person needs the stronger drug. What they establish is that the premium is not for a brand name — it is for a different molecule with a different evidence base, set out in full on semaglutide against tirzepatide: the evidence.
Staying on semaglutide
Semaglutide works on one receptor, GLP-1; tirzepatide adds a second — see how semaglutide works. Moving between them is a new prescription with its own titration, and neither label publishes a dose conversion, which is covered in switching sellers, or switching molecules.
If what you want is a lower bill rather than a different drug, the cheaper move is usually inside the semaglutide market, where the spread between sellers is wider than most step ups on this page. Start with the cheapest semaglutide at every dose. The tirzepatide market is priced the same way on Compounded Tirzepatide, which the same people publish.
Questions
- How much more is compounded tirzepatide than compounded semaglutide?
- At the same seller, a median of $81 a month more, across 365 sellers that sell both. At 65 of them the difference is $50 a month or less.
- Is compounded tirzepatide worth the extra over semaglutide?
- That is a clinical question, not a price one. In the head-to-head SURMOUNT-5 trial of the approved drugs, weight fell by 20.2% on tirzepatide against 13.7% on semaglutide over 72 weeks. Whether that difference matters for a particular person is for a prescriber to judge.
- Which sellers sell both compounded semaglutide and tirzepatide?
- 365 sellers publish a computable monthly price for both. The ones where tirzepatide costs least extra are listed on this page, smallest step up first.
- Can I switch from semaglutide to tirzepatide at the same dose?
- No. The two are different molecules with different dose ranges, neither approved label publishes a conversion between them, and tirzepatide is started at its own low dose and titrated up again.
Price information only. Nothing here is medical advice, and the more expensive molecule is not therefore the right one.
Sources
- This site's price index, computed from what sellers actually bill Read it
- Compounded Tirzepatide, our sister index at compoundedtirzepatide.org — same publisher, same method
- SURMOUNT-5 (New England Journal of Medicine 2025) and SURPASS-2 (New England Journal of Medicine 2021), as summarized on our research page