Compounded semaglutide

Signos review

By ·Editor·Reviewed

Signos sells compounded semaglutide only as part of Signos+, a bundle that pairs the injection with a Dexcom glucose sensor and its app. Standard-dose semaglutide bills $249 every 28 days on a 12-week plan, which averages about $271 a calendar month. The shortest commitment is 12 weeks, and it renews for another 12 unless you cancel.

A real month costs$271advertised $199 +$71.68 gap
EvidenceVerified
Billing cycle4-wk
Price across dosesSame at every dose
Where it shipsClaims every state
FDA warning letterNone found
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On this page

Is it right for you?

Worth a look if

  • You want to see how food, sleep and movement move your glucose while you take semaglutide.
  • You're happy to commit to 12 weeks at a time rather than month to month.
  • You'd use a dietitian and an app alongside the medication, since both come in the same charge.

Skip it if

  • You only want the medication and have no use for a glucose sensor.
  • You want to stop after a single month without risking an early cancellation fee.
  • You expect to pay the $199 a month shown on the plans page for standard-dose semaglutide.

What's included

Each Signos+ charge covers the semaglutide and injection supplies, Stelo glucose sensors by Dexcom, the Signos app, unlimited clinician support, dietitian support and free shipping. There is no separate membership line. Signos' terms say medication costs are included in the program price.

The $199 a month headline on the plans page is the microdose price on the longer 24-week plan. Standard-dose semaglutide on the 12-week plan is $249 per charge. A 24-week plan lowers the per-charge figure if you're sure you'll stay.

Signos itself is a technology company. Prescribing is done by clinicians at OpenLoop Health. Its four contracted pharmacies are named in the terms: RedRock Pharmacy in Utah, Health Warehouse in Kentucky, Precision Medicine in New York and Triad Rx in Alabama. The semaglutide is compounded and not FDA-approved.

From sign-up to refills

  1. Take the quiz on Signos' plans page. It starts with your date of birth, sex and state, then moves into health history and medication questions.
  2. Pick semaglutide, a dose type and a 12-week or 24-week plan. You're charged the first $249 at checkout.
  3. An OpenLoop clinician reviews your answers asynchronously. Most members are approved without a video visit, though some cases need a short one.
  4. If you're approved, the medication and the glucose sensors ship separately, each with its own tracking email.
  5. When the first box arrives, download the Signos app and pair the sensor. Charges repeat every 28 days for the rest of the term.

What's good, what isn't

What's good

  • Every Signos+ plan includes Dexcom's Stelo sensor, which reads glucose every five minutes without finger pricks.
  • Dietitian chat and unlimited clinician support from OpenLoop come inside the $249 charge.
  • The terms name all four partner pharmacies, including RedRock Pharmacy and Health Warehouse, with addresses.

What isn't

  • Semaglutide bills every 28 days, so a year on the 12-week plan brings 13 charges, not 12.
  • Canceling during an active 12-week term can trigger an early cancellation fee under Signos' checkout consent.
  • Outside a medical disqualification, OpenLoop's policy allows no refund when you cancel the subscription.

Read these terms first

The 12-week term
The checkout consent authorizes a charge today and two more every 28 days, covering 12 weeks. The plan then renews for another 12-week term unless you cancel first.
Cancellation notice
OpenLoop's policy asks for a cancellation request at least 72 hours before the next billing date. A late request means one more charge before the cancellation takes effect.
Introductory discounts
The checkout consent states that discounts do not carry into renewals. If a code lowers your first term, budget for the full $249 per charge after it.
If you're not approved
When a clinician declines GLP-1 treatment, Signos presents other options, and you can choose a full refund instead.

Price

Signos costs $271 a month for compounded semaglutide. It advertises $199. The card is charged $249 every 4 weeks.

How we got $271

The arithmeticOne month = 30.4375 days

  1. Signos advertises

    Read on Signos's own site

    $199.00

  2. The card is charged $249.00, not $199.00

    The advertised figure is not the amount that leaves the account.

    + $50.00

  3. And it is charged every 4 weeks, not every month

    13.04 charges a year, not twelve.

    + $21.68

A real month$270.68

A real month costs $71.68 more than the figure advertised.

Where it sits, and what costs less

$54median $199$325+

308 cheaper · 81%63 dearer · 17%

The most expensive 10 sellers charge between $325 and $540 a month.

  1. Fidelity Medical Clinicstarting dose$54
  2. Collective$76
  3. NextMeds$79
  4. Lean Meds$79
  5. RxPepsDirectstarting dose$80
  6. Signos$271

Another 303 sellers are cheaper than Signos. The whole cheapest list →

Where it says it operates

Signos is currently available in the United States and ships to all 50 states.

Read on its own site in August 2026. That is the seller’s own promise for the whole country, so confirm your state when you sign up.

State pages this seller appears on: AL AK AZ AR CA CO CT DE DC FL GA HI ID IL IN IA KS KY LA ME MD MA MI MN MS MO MT NE NV NH NJ NM NY NC ND OH OK OR PA RI SC SD TN TX UT VT VA WA WV WI WY

What else this seller sells

The same seller appears in our data for one other medication.

Each figure is a real month for that medication, and none of it is part of the compounded semaglutide price above. How the two molecules compare at every seller that sells both: compounded semaglutide vs compounded tirzepatide.

Common questions about Signos

Is Signos legit?
Signos is a metabolic health company whose app works with Dexcom's Stelo glucose sensor. For semaglutide it acts as the platform only. OpenLoop Health's licensed clinicians decide who is prescribed, and contracted U.S. pharmacies fill the orders. Signos says plainly that the compounded semaglutide is not FDA-approved.
How much is Signos semaglutide per month?
Standard-dose semaglutide on the 12-week Signos+ plan is $249 every 28 days, about $271 averaged over a calendar month. That covers the medication, glucose sensors, app, clinician and dietitian support, and shipping. The $199 starting figure is the microdose price on the 24-week plan.
Can you cancel Signos?
Yes, from your portal or through Signos customer service. Send the request at least 72 hours before a billing date. Canceling partway through a 12-week term may bring an early cancellation fee, and payments already made are not refunded unless a clinician disqualifies you.
Does Signos include a glucose monitor with semaglutide?
Yes. Every Signos+ plan bundles Stelo sensors by Dexcom with the medication, and the price has no separate sensor fee. Each sensor lasts 15 days and sends readings to the Signos app on your phone.