Drug facts

Microdosing semaglutide

By David Chen·Editor·Reviewed September 2026

Is there a microdosing chart?¹

Not an official one. Charts shared online under that name are made by sellers or clinics, and none of them comes from the label. The only dosing chart the label prints is its escalation table, which is the chart below. Every row is a dose that was tested; nothing sits below the first one.

Ozempic, the diabetes product, starts the same way: 0.25 mg once weekly for 4 weeks, then 0.5 mg. From there its maintenance doses are 0.5, 1 or 2 mg, and 2 mg is its maximum.³

The label also allows the climb to slow down. If a dose is not tolerated during escalation, it says to consider delaying the next step by 4 weeks. That is the only flexibility it describes, and it stretches the time on a tested dose; it does not create a smaller one. The full chart, and how a compounded vial’s strength turns a dose into a syringe mark, is on the dosage chart.

A smaller dose does not always mean a smaller bill, because many sellers charge one price at every dose. Among the sellers we work with, the Shed review records $199 a calendar month at every dose, the RxSpan MD review $249 a calendar month and the Oak review $250 a calendar month at the starting dose. We may earn a commission from these sellers, and the full index orders every seller by price alone.

The word is not in the label⁵

Neither “microdose” nor “microdosing” appears anywhere in the published Wegovy label, including its Medication Guide and instructions for use. That is worth stating precisely. Sellers use the term freely, and it suggests an established practice with a known dose range, which the label does not describe.

What the lowest approved dose is for¹

0.25 mg is a starting dose. The label tells prescribers to follow the escalation table “to reduce the risk of gastrointestinal adverse reactions,” and the maintenance dose for weight reduction in adults is 1.7 or 2.4 mg, reached at week 17. A dose that is never increased from is not a dose the schedule describes.

Is there a microdosing schedule?²

The label has one schedule, and it is weekly: one injection on the same day each week, at any time of day, with or without meals. It does not describe a dose every other week, a split dose, a daily dose of the injection, or a lower dose kept long term. None of those patterns was tested in the trials behind the label, so it gives no rate, effect size or safety profile for them.

What it does describe is how to move the weekly day.⁴ The Wegovy Medication Guide says the day can change as long as the last dose was 2 or more days before, and missed doses are on the missed-dose page.

What that absence does and does not mean⁵

It does not mean a lower dose is dangerous, and it does not mean it does nothing. It means the approved trials did not test it, so no one can quote a rate, an effect size or a safety profile for it from this label. A figure presented as if they could has come from somewhere else.

It is also a question about cost. A smaller dose from the same vial lasts longer, so “microdosing” is partly a claim about price. What a vial costs per calendar month is on the index, and it does not depend on how the dose is described. Your dose itself is your prescriber’s decision.

What sellers sell as a microdose plan⁶

Where the label is silent, the market is not. Among the sellers on this site, 94 offer something they call a microdose, and between them that comes to 105 plans. Each appears below under the name its seller gives it, beside the price that seller led with when we read its page in September 2026; 19 publish no figure on the page itself. A page that sells a “GLP-1 microdose” without saying which drug is in it is still listed.

None of these is a smaller rung of the Wegovy or Ozempic schedule, which begins at 0.25 mg with nothing beneath it. Nor can the prices be lined up as monthly costs: a figure may be an introductory month, a rate that holds only on a prepaid bundle, or the cost of one vial, and the period printed beside it says which. For that reason the rows run alphabetically by seller, not cheapest first. What each seller charges per calendar month for its standard vials is on the price index.